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Vabljeno predavanje prof. Khoo, National University of Singapore

04.09.2015

Vabimo vas na  predavanje prof. Khoo-ja, National University of Singapore. Predavanje bo v ponedeljek, 7. septembra ob 15:00 v predavalnici  Laboratorija za slikovne tehnologije (4. nadstropje stare stavbe).

Naslov: High Intensity Focused Ultrasound (HIFU) for biomedical and dentistry application

Povzetek:

We study the physical phenomena and the application of HIFU using simulation and experiment. The experiment was done with a bowl-shaped focused ultrasound system. High speed videos of the generation of cavitation bubbles at the focal point of the HIFU are captured. We observed interesting bubble cloud structures, bubble movements and stationary bubble oscillations. The system is then applied for dentistry applications. Firstly we use the HIFU to drive antibacterial nanoparticles into dentinal tubules for disinfection in root canal treatment. Initial results show delivery of these nanoparticle deep into the dentinal channels which are a few microns in size. Next we cultivate E. Faecalis biofilm, a common bacteria colony found in the mouth and teeth, on petri dish and in human tooth. Then we subject them for removal under strong HIFU for 1 to 2 minutes. We obtain positive results in the biofilm removal with the increasing HIFU sonification time. We also simulate the interaction of a bubble with pulsed ultrasound and in an ultrasound field near bio-materials such as fat, muscle and bone. The simulation shows extreme growth and collapse of the bubble under certain conditions. Also the formation and direction of the water jet during bubble collapse is highly dependent on the properties of the bio-materials nearby. These studies provide a foundation for better understanding of HIFU and its uses in medical treatment.

Predavatelj:

• KHOO Boo Cheong, Director, Teamsek Laboratories, Professor, Department of Mechanical Engineering, Faculty of Engineering, National University of Singapore

BC Khoo graduated from the University of Cambridge with a BA (Honours, 1st Class with Distinction) in 1980 under the Overseas Merit Scholarship and President’s Scholarship. In 1984, he obtained his MEng from the NUS and followed by PhD from MIT in 1989. He joined NUS in 1989.

From 1998 to 1999, he was seconded to the Institute of High Performance Computing (IHPC, Singapore) and served as the deputy Director and Director of Research.

In 1999, BC returned to NUS and spent time at the SMA-I (Singapore MIT Alliance I) as the co-Chair of High Performance Computation for Engineered Systems Program till 2004. In the period 2005-2013, under the SMA-II, he was appointed as the co-Chair of Computational Engineering Program.

In 2011-2012, BC was appointed the Director of Research, Temasek Laboratories. Since 2012, he has been the Director, Temasek Laboratories.

BC Khoo serves on numerous organising and advisory committees for International Conferences/Symposiums held in USA, China, India and Singapore. He is a member of the Steering Committee, HPC (High Performance Computing) Asia. He has received a Defence Technology Team Prize (1998) and the prestigious Royal Aeronautical Prize (1980, UK). Among other numerous and academic and professional duties, he is the Associate Editor of Communications in Computational Physics (CiCP) and Advances in Applied Mathematics and Mechanics (AAMM), and is on the Editorial Board of American Journal of Heat and Mass Transfer, Ocean Systems Engineering (IJOSE), International Journal of Intelligent Unmanned Systems (IJIUS), The Open Mechanical Engineering Journal (OME) and The Open Ocean Engineering Journal.

In research, BC ‘s interest are in:

• Fluid-structure interaction
• Underwater shock and bubble dynamics
• Compressible/Incompressible multi-medium flow

He is the PI of numerous externally funded projects including from the Defense agencies to simulate the WSSA and the dynamics of bubble(s) with extension to cavitation. His work on water circulation and transport across the turbulent air-sea interface has received funding from BP International for predicting the effects of accidental chemical spills.

Website: http://serve.me.nus.edu.sg/khoobc/